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目的:评价两性霉素B与氟康唑滴眼液对真菌性角膜炎患者抗真菌的临床疗效。方法:选取医院2015年1月—2016年1月间收治的真菌性角膜炎患者82例,将其随机分为对照组和治疗组,每组41例;对照组患者给予两性霉素B滴眼液治疗,治疗组患者在对照组治疗的基础上加用氟康唑滴眼液治疗,比较两组患者治疗后有总有效率和各症状消失时间。结果:治疗组患者临床治疗后的总有效率为97.56%高于对照组为80.49%(P<0.05),角膜溃疡、前房脓肿、畏光和异物感消失时间分别明显短于对照组(P<0.05)。结论:两性霉素B与氟康唑滴眼液联用治疗真菌性角膜炎患者的临床疗效优于单用两性霉素B,眼疾症状消失时间快,不影响正常视力。
Objective: To evaluate the clinical efficacy of amphotericin B and fluconazole in the treatment of fungal keratitis patients. Methods: 82 patients with fungal keratitis admitted from January 2015 to January 2016 in our hospital were randomly divided into control group and treatment group, 41 cases in each group. The control group was given amphotericin B eye drops Fluid treatment, treatment group patients in the control group based on the treatment with fluconazole eye drops treatment, the two groups were compared after treatment with the total effective rate and the disappearance of the symptoms of the time. Results: The total effective rate of the treatment group after treatment was 97.56%, which was significantly higher than that of the control group (80.49%, P <0.05). The disappearance time of corneal ulcer, anterior abscess, photophobia and foreign body sensation was significantly shorter than that of the control group <0.05). Conclusion: The clinical efficacy of amphotericin B combined with fluconazole eye drops in the treatment of patients with fungal keratitis is superior to that of amphotericin B alone. The symptoms of eye diseases disappear quickly and do not affect normal vision.