以两步乳匀法制备氟比洛芬酯(1)脂微球注射液。采用单因素法结合正交试验优化得到的制备工艺为:乳化温度65℃,20 000 r/min高速剪切8 min,1 000 bar高压均质6次,再调节pH值至8.5,灌装熔封于5 ml安瓿,115℃高压灭菌30 min。优化制品灭菌后的脂微球粒径约200 nm,ζ电位为-36 mV,包封率为99.3%,pH值约7.0。 Preparation of flurbiprofen axetil (1) lipid microsphere injection by two steps homogenization. The optimum preparation conditions were as follows: emulsifying temperature 65 ℃, high speed cutting at 20 000 r / min for 8 min, homogenization under high pressure of 1000 bar for 6 times, adjusting the pH value to 8.5, filling and melting Enclosed in 5 ml ampoules, autoclaved at 115 ° C for 30 min. The optimized microspheres were about 200 nm in diameter and-36 mV in zeta potential. The encapsulation efficiency was 99.3% and the pH value was about 7.0.