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目的 :探讨内皮型一氧化氮合酶基因多态性与妊高征的相关性。方法 :应用PCR -RFLP技术检测了 12例正常女性的内皮型一氧化氮合酶基因第 7外显子。结果 :发现 12例正常女性中有 4例的基因型是eNOS/GG ,有 8例的基因型是eNOS/GT ,未检测到eNOS/TT型的个体。等位基因A1(eNOS/G)的频率为 66 7% ,等位基因A2 (eNOS/T)的频率为 33 3%。结论 :广东女性人群存在内皮型一氧化氮合酶第 7外显子BanⅡ酶切位点遗传多态性。
Objective: To investigate the relationship between endothelial nitric oxide synthase gene polymorphism and pregnancy-induced hypertension. Methods: PCR-RFLP technique was used to detect exon 7 of endothelial nitric oxide synthase gene in 12 normal women. RESULTS: Four of the 12 normal women were found to have eNOS / GG genotypes. Eight of the eight genotypes were eNOS / GT and no eNOS / TT genotype was detected. The frequency of allele A1 (eNOS / G) was 66.7% and the frequency of allele A2 (eNOS / T) was 33.3%. Conclusion: The genetic polymorphism of exon 7 Ban Ⅱ enzyme digestion site of endothelial nitric oxide synthase exists in Guangdong female population.