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目的:探讨冠心病稳定性心绞痛患者血清脂联素(APN)水平变化与C反应蛋白(CRP)的关系。方法:测定40例稳定性心绞痛患者的血清,30例为对照组(冠脉造影正常体检人员)分别检测血清脂联素,高敏CRP(hs-CRP)水平,并比较两者的相互关系。结果:稳定性心绞痛组与对照组比较血清脂联素水平的对数值明显低于对照组(P<0.01,HS(CRP)的对数值则高于对照组(P<0.01),两者呈明显的负相关。结论:血清脂联素水平降低与冠心病心绞痛有关,脂联素参与了冠状动脉粥样硬化的发展过程。
Objective: To investigate the relationship between serum adiponectin (APN) level and C-reactive protein (CRP) in patients with coronary heart disease and stable angina. Methods: The serum levels of adiponectin and hs-CRP were measured in 40 patients with stable angina pectoris and 30 patients in the control group (normal coronary angiography). The correlation between them was also analyzed. Results: The logarithm of serum adiponectin level in stable angina pectoris group was significantly lower than that in control group (P <0.01, the logarithm value of HS (CRP) was higher than that in control group (P <0.01) .Conclusion: The decrease of serum adiponectin level is associated with angina pectoris. Adiponectin participates in the development of coronary atherosclerosis.