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目的 探讨Th1/Th2细胞类型与疾病活动指数之间的关系。方法 利用流式细胞分析法对系统性红斑狼疮 (SLE)患者无尿蛋白组 2 1例 ,有尿蛋白组 2 7例和健康志愿者 15名外周血中淋巴细胞的胞内细胞因子 (INF γ、IL 4)和表面抗原 (CD4)进行分析。结果 SLE患者组和无尿蛋白组与健康志愿者Th1/Th2细胞比值无明显区别 (P >0 0 5 ) ,但SLE尿蛋白组患者Th1/Th2细胞比值显著高于SLE无尿蛋白组和健康志愿组 (P <0 0 5 )。尿蛋白组患者Th1和Th1/Th2比值与疾病活动指数之间呈明显的正相关 (P <0 0 5 )。结论 虽然SLE被认为是一种Th2细胞占优势的疾病 ,Th1/Th2的比值目前研究未表现这些细胞为优势 ;相反 ,在SLE患者中狼疮肾炎有强的Th1优势 ,其程度与疾病活动性密切相关。
Objective To investigate the relationship between Th1 / Th2 cell type and disease activity index. Methods Flow cytometry was used to detect the expression of intracellular cytokines (INF γ γ) in peripheral blood lymphocytes from 21 patients with systemic lupus erythematosus (SLE) without urinary protein, 27 with urine protein and 15 healthy volunteers , IL 4) and surface antigen (CD4). Results There was no significant difference in Th1 / Th2 ratio between SLE patients and non-urine protein patients (P> 0.05), but the Th1 / Th2 ratio in patients with SLE urinary protein was significantly higher than that of SLE urineless patients and healthy Volunteer group (P <0 05). Urinary protein group of Th1 and Th1 / Th2 ratio and disease activity index showed a significant positive correlation (P <0 05). Conclusions Although SLE is considered to be a predominant disease of Th2 cells, the ratio of Th1 / Th2 is not predominantly presently demonstrated by these studies; in contrast, lupus nephritis has a strong Th1 predominance in SLE patients to a degree that is closely related to disease activity Related.