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目的探讨短期模拟失重环境对成人执行功能的影响。方法成年男性志愿者20名,记录头低位(head-down tilt,HDT)-6°卧床前一天(HDT/0d)和卧床7 d(HDT/1d~HDT/7d)的Go/Nogo任务反应,分析执行功能是否受到模拟失重生理环境的影响及其随时间的变化趋势。结果 HDT前后各天的Go/Nogo任务结果中,平均反应时(F=0.905,P>0.05)与击中率(F=2.026,P>0.05)均无显著性差异,而虚报率(F=2.705,P<0.05)有差异,两两比较后发现HDT/3d,HDT/4d和HDT/5d的虚报率皆高于HDT/0d和HDT/6d的虚报率。结论大脑执行功能有可能在HDT的初期受到损害或抑制,但在中后期又会恢复,说明在微重力环境下,脑功能可能存在自我调节机制。
Objective To investigate the effect of short-term simulated weightlessness environment on adult executive function. Methods Twenty adult male volunteers were enrolled in this study. The Go / Nogo task response was recorded on the day before bed-down tilt (HDT) -6 ° HDT / 0d and HDT / HD on the 7th day. Analyze whether executive function is affected by simulated weightlessness physiological environment and its changing trend with time. Results Among the Go / Nogo tasks on the day before and after HDT, there was no significant difference between the average response time (F = 0.905, P> 0.05) and the hit rate (F = 2.026, P> 0.05) 2.705, P <0.05). After comparison, the false alarm rates of HDT / 3d, HDT / 4d and HDT / 5d were all higher than those of HDT / 0d and HDT / 6d. Conclusion The executive function of the brain may be impaired or inhibited in the early stage of HDT, but recovered in the middle and late stages, indicating that there may exist a mechanism of self-regulation of brain function under the condition of microgravity.