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临床上漏诊缺镁教训屡有报告,但尚未引起临床工作者足够的重视,故在复习文献基础上,仅就我们点滴体会综述如下。一、镁与缺血性心脏病 1、镁与心肌代谢:有人证实,镁对心肌兴奋作用与钙相似,但两者又相拮抗。如在细胞外液中存在钙时,镁对心肌电位活动几乎无作用;若除去钙,镁量增加时,其阀值增大,活动电位持续时间也缩短。并证明:镁能抑制血管运动神经和迷走神经,使冠状动脉扩张。这是由于当镁直接作用于肌肉和神经连接点时,突触囊和运动终板处释放出的乙酰胆硷与钙连接作用可被镁所拮抗。同时镁还参与胶原纤维对ATP的水解和肌凝蛋白
Clinically missed diagnosis of magnesium deficiency have repeatedly reported, but not enough attention has been caused by clinical workers, so in reviewing the literature based on only a bit of our experience summary is as follows. First, magnesium and ischemic heart disease 1, magnesium and myocardial metabolism: It was confirmed that magnesium on myocardial excitability and calcium similar, but both antagonistic. If calcium is present in the extracellular fluid, magnesium has little effect on myocardial electrical activity; if calcium is removed, the threshold increases and the duration of the activity potential shortens as the amount of magnesium increases. And proved: Magnesium can inhibit the motor and vagus nerve blood vessels, the coronary artery dilatation. This is due to the fact that acetylcholine released from synaptic vesicles and motor endplates can be antagonized by magnesium when magnesium acts directly on muscle and nerve junctions. At the same time, magnesium is also involved in the hydrolysis of collagen fibers and myosin