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幽门螺杆菌(Hp)是革兰阴性菌,可定植于人胃黏膜,导致胃炎、消化性溃疡、胃腺癌和胃黏膜相关性淋巴瘤。世界上约有半数以上的人被感染,1994年被世界卫生组织确定为第1类致癌因子。在台湾,它是居第4位的致癌因素。同一致病菌可引起不同的结局,细菌毒力、环境因素、宿主因素被认为是三大主要原因。Hp能长期定植于人胃黏膜,是由于Hp分泌一系列毒力决定因子,协助其黏附、定植和适应胃酸性环境的变化。在这些因素中,细胞空泡毒素(VacA)、细胞毒素相
Helicobacter pylori (Hp) is a gram-negative bacterium that colonizes human gastric mucosa and causes gastritis, peptic ulcer, gastric adenocarcinoma and gastric mucosa-associated lymphoma. About half of the world’s people are infected, in 1994 by the World Health Organization identified as a type 1 carcinogen. In Taiwan, it is the No. 4 carcinogen. The same pathogen can cause different outcomes, bacterial virulence, environmental factors, host factors are considered to be the three major causes. Hp colonization of human gastric mucosa for a long time, is due to Hp secretion of a series of virulence determinants to assist its adhesion, colonization and adapt to changes in gastric acid environment. Among these, cell vacuolar toxin (VacA), cytotoxic phase