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目的探讨咪唑类药物对７３例（７３只眼）丝状真菌性角膜炎治疗的疗效。方法将７３例随机分为四组，Ⅰ组采用咪康唑混悬液滴眼（２３例），Ⅱ组用复方咪唑蓖麻油溶液（１５例）滴眼、Ⅲ组用复方咪唑粉撒布（１９例），Ⅳ组用复方咪唑粉撒布联合局部清创术（１６例）。除Ⅰ组外，其余三组均联合酮康唑口服。结果各组治愈率分别为２１．７４％、６６．６７％、７３．６８％及９３．７５％，平均治愈天数分别为６５、６８、３５及１９天。Ⅳ组分别与前三组治愈率及平均治愈天数比较，差异均有显著性（Ｐ＜０．０１）。结论咪唑粉撒布联合局部清创术是治疗丝状真菌性角膜炎的一种较好的治疗方法。
Objective To investigate the therapeutic effect of imidazole on 73 cases (73 eyes) of filamentous fungal keratitis. Methods 73 cases were randomly divided into four groups. Group I was treated with miconazole suspension (23 cases). Group II was treated with compound imidazole castor oil solution (15 cases). Group III was treated with compound imidazole powder (19 Cases), Ⅳ group with compound imidazole powder combined with local debridement (16 cases). In addition to group I, the other three groups were combined with ketoconazole orally. Results The cure rates of each group were 21.74%, 66.67%, 73.68% and 93.75%, respectively. The average cure days were 65, 68, 35 and 19 days respectively. There was significant difference between the Ⅳ group and the first three groups in the cure rate and the average cure time (P <0.01). Conclusion The combination of imidazole powder and local debridement is a good treatment for the treatment of filamentous fungal keratitis.