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目的分析和探讨前列腺间叶性肿瘤的临床病理特征。方法对14例前列腺间叶性肿瘤的临床病理特征进行形态学观察、免疫组化染色以及术后随访。结果 10年中共行前列腺穿刺活检1072例,诊断前列腺间叶性肿瘤14例(1.3%),其中原发性间叶性肿瘤12例(86%),包括前列腺特殊间质肿瘤4例(1例恶性潜能不确定的间质肿瘤,3例间质肉瘤)、孤立性纤维性肿瘤3例、胃肠间质瘤1例,梭形细胞肉瘤(倾向为间质肉瘤)4例;继发性间叶性肿瘤2例(14%)。临床表现为进行性排尿困难12例,所有患者经直肠指诊均可触及前列腺明显增大;12例血清PSA 0.06～3.87 ng/ml,平均1.67 ng/ml。结论前列腺间叶性肿瘤主要为原发性间叶性肿瘤,前列腺特殊间质来源肿瘤是前列腺间叶性肿瘤中最常见的肿瘤类型,其次为孤立性纤维性肿瘤,患者往往较年轻。
Objective To analyze and explore the clinicopathological features of prostate mesenchymal tumors. Methods The clinicopathological features of 14 cases of prostate mesenchymal tumor were observed by morphology, immunohistochemistry and follow-up. Results A total of 1072 prostate biopsy specimens were performed in 10 years. Fourteen patients (1.3%) were diagnosed as prostate mesenchymal tumors. Among them, 12 (86%) were primary mesenchymal tumors including 4 prostate specific stromal tumors (1 patient 3 cases of interstitial sarcoma), 3 cases of isolated fibrous tumor, 1 case of gastrointestinal stromal tumor, 4 cases of spindle cell sarcoma (predominantly stromal sarcoma), 4 cases of secondary interstitial tumor Two cases of leaf tumors (14%). Clinical manifestations of progressive dysuria in 12 cases, all patients can reach the prostate by rectal examination significantly increased prostate; 12 cases of serum PSA 0.06 ~ 3.87 ng / ml, an average of 1.67 ng / ml. Conclusions Prostate mesenchymal tumors are mainly primary mesenchymal tumors. Prostate-derived mesenchymal tumors are the most common tumor types in prostate mesenchymal tumors, followed by solitary fibrous tumors, and patients are often younger.