论文部分内容阅读
目的:研究纤维支气管镜(简称纤支镜)抽吸物中异质性细胞核核糖蛋白A2/B1(HnRNP A2/B1)的表达与肺癌的相关性及其用于肺癌诊断的可行性。方法:利用免疫细胞化学的方法检测经病理学或(和)细胞学确诊的肺癌患者和非肺癌患者的纤支镜抽吸物中HnRNP A2/B1的表达情况,并分析其表达水平的差异性。结果:1) HnRNP A2/B1 在肺癌组和非肺癌组患者纤支镜抽吸物中表达阳性率分别为68. 6%(83/121)和13. 6%(3/22),两组比较差异有统计学意义,P<0. 05。2) HnRNPA2/B1在不同病理类型中表达阳性率也不同,鳞癌为67. 6% ( 50/74 ), 腺癌为60. 0%(18/30),小细胞癌为88 2%(15/17),差异有统计学意义,P< 0 .05。结论: HnRNP A2/B1 在肺癌患者纤支镜抽吸物中表达的敏感性为68 .6%(83/121),特异性为86. 4%(19/22),可用于肺癌的诊断。
Objective: To investigate the correlation between the expression of heterozygous nuclear ribosomal protein A2 / B1 (HnRNP A2 / B1) and lung cancer in bronchoscope and its feasibility for diagnosis of lung cancer. Methods: Immunocytochemistry was used to detect the expression of HnRNP A2 / B1 in bronchogenic aspirates from patients with pathologically or (and) cytologically diagnosed lung cancer and non-lung cancer, and to analyze the differences in the expression of HnRNP A2 / . Results: 1) The positive rates of HnRNP A2 / B1 expression in bronchogenic aspiration in lung cancer group and non-lung cancer group were 68.6% (83/121) and 13.6% (3/22), respectively The difference was statistically significant, P <0. 05.2) HnRNPA2 / B1 in different pathological types of positive expression rate is also different, squamous cell carcinoma was 67. 6% (50/74), adenocarcinoma was 60.0% ( 18/30), small cell carcinoma was 88 2% (15/17), the difference was statistically significant, P <0 .05. Conclusion: The sensitivity of HnRNP A2 / B1 expression in lung cancer patients with bronchoscopic aspiration was 68.6% (83/121) and specificity was 86.4% (19/22), which could be used for the diagnosis of lung cancer.