近几年,越来越多的证据表明~([1]),在肿瘤形成过程中除了细胞的癌基因和抑癌基因活化和失活,机体免疫监视系统的逃逸也是不容忽视的重要因素,肿瘤细胞可以通过某些途径逃逸或者抑制机体免疫反应而确保其自身的发生发展。而Treg是一群具有免疫抑制功能的负调控细胞,它们在维持外周免疫耐受,预防自身免疫疾病的发生过程中起着重要作用。CD4~+CD25~+Treg是Treg重要组成部分,随着对CD4~+CD25~+Treg认识的不断深入,它在 In recent years, there is more and more evidence that ~ ([1]), in addition to the activation and inactivation of oncogenes and tumor suppressor genes in tumorigenesis, escape of the immune surveillance system is an important factor that can not be ignored. Tumor cells can escape or suppress the immune response in some ways to ensure their own development. Treg, a group of negative regulatory cells with immunosuppressive functions, plays an important role in maintaining peripheral immune tolerance and preventing the development of autoimmune diseases. CD4 ~ + CD25 ~ + Treg is an important component of Treg, with the understanding of CD4 ~ + CD25 ~ + Treg deepening, it is