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应用辣椒素毁损大鼠肽能感觉神经,观察缺氧性肺血管收缩反应(HPV)和缺氧性脑血管舒张反应(HCVD)变化,用放射免疫测定法和免疫组化法观察急性缺氧时肺内感觉神经肽的变化,及其与外源性P物质(SP)对大鼠HPV和HCVD的影响.结果发现,辣椒素处理的大鼠平均肺动脉压、肺血管阻力及缺氧性肺血
Capsaicin was applied to destroy the sensory nerves in rats and the changes of hypoxic pulmonary vasoconstriction (HCVD) and hypoxic cerebral vasodilation (HCVD) were observed. Acute hypoxia was observed by radioimmunoassay and immunohistochemistry The change of sensory neuropeptide in the lung and its effect on the HPV and HCVD in rats were detected by exogenous substance P. It was found that the average pulmonary arterial pressure, pulmonary vascular resistance and hypoxic pulmonary blood