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目的研究动脉粥样硬化性脑梗死（ＡＣＩ）患者血脂水平与载脂蛋白Ｂ（ＡｐｏＢ）基因多态性及性别之间的相关性。方法运用聚合酶链反应－限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）对８６例ＡＣＩ患者和５５例正常对照（ＮＣ）进行ＡｐｏＢ的基因分析。结果①两组间等位基因频率分布无差异（Ｐ＞０．０５）；②两组间存在总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白（ＬＤＬ）、载脂蛋白Ａ（ＡｐｏＡ）、载脂蛋白Ｂ（ＡｐｏＢ）、脂蛋白（ａ）［Ｌｐ（ａ）］水平的差异（Ｐ＜０．０５）；③ＡＣＩ组血脂水平异常与性别有关（Ｐ＜０．０５）。结论ＡｐｏＢ基因多态性对ＡＣＩ患者血脂水平无明显影响；性别对脂质代谢有一定影响。
Objective To investigate the association between serum lipids and apolipoprotein B (ApoB) gene polymorphism and sex in patients with atherosclerotic cerebral infarction (ACI). Methods ApoB gene analysis was performed in 86 ACI patients and 55 normal controls (NC) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results ① There was no significant difference in allele frequency distribution between the two groups (P> 0.05). ② There were significant differences in total cholesterol (TC), triglyceride (TG), low density lipoprotein ApoA, ApoB and Lp (a)] (P <0.05). (3) The abnormal lipid level in ACI group was related to sex (P <0.05). Conclusion ApoB gene polymorphism has no significant effect on blood lipids in ACI patients; sex has a certain impact on lipid metabolism.