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目的 :讨论大鼠中脑导水管周围灰质 (PAG)内源性阿片肽和神经降压素 (NT)在痛觉调制中的相互关系。方法 :以钾离子透入法引起大鼠甩尾反应的电流强度 (mA)为痛行为反应的指标 ,观察向PAG内注入NT、钠洛酮、抗甲 -脑啡肽血清、抗 β-内啡肽血清和抗强啡肽A1～ 13 血清 ,对动物痛阈的影响。结果 :PAG内注入纳洛酮、抗甲 -脑啡肽血清和抗 β -内啡肽血清后 ,可明显减弱NT的镇痛效应 ,注入抗强啡肽血清后 ,对NT的镇痛效应无显著影响。结论 :PAG内NT在痛觉调制中的作用至少部分与PAG内的内源性甲 -脑啡肽和 β-内啡肽血清有密切关系
PURPOSE: To discuss the relationship between endogenous opioid peptide (PAG) and neurotensin (NT) in pain modulation in rat middle cerebral aqueduct. Methods: The current intensity (mA) induced by potassium iontophoresis in rat tail flick reaction was used as an indicator of pain behavior. The effects of NT, sodium, ketoprofen, anti-A-enkephalin, Effects of serum and anti-dynorphin A1 ~ 13 serum on pain threshold in animals. Results: The injection of naloxone, anti - A - enkephalin serum and anti - β - endorphin serum in PAG significantly attenuated the analgesic effect of NT. After injection of anti - dynorphin serum, the analgesic effect on NT was absent Significantly affected. CONCLUSIONS: The role of NT in PAG on pain modulation is at least partly related to the endogenous N-enkephalin and β-endorphin sera in PAG