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终止中期妊娠最普遍使用的方法包括羊膜腔内注入PGF_(2a),PGE_2或羊膜腔外注射同样的PGs或利凡诺尔,近来报告肌肉注射或阴道内应用PG类似物效果较好。阴道使用的前列腺素类有ono-802和9-去氧-16,16双甲基-9-乙烯基PGE_2栓剂。最近改为9-乙烯基PG类阴道亲水性凝胶,明显提高了药物生物利用度,用药量则相应减低。抗孕激素RU_(486)可在受体水平与孕酮竞争,口服后可使子宫肌层对前列腺素敏感,已知它与前列腺素类联合应用,可成功地终止早期妊娠。现对中孕引产时使用RU486是否可缩短引流时间,减少副作用进行研究。
The most commonly used methods for terminating midterm gestation include intra-peritoneal injection of PGF2a, PGE2, or amniotic injection of the same PGs or rivanol, and recent reports of intramuscular or intravaginal administration of PG analogs are better. Vaginal prostaglandins are ono-802 and 9-deoxy-16,16 bis-methyl-9-vinyl PGE 2 suppositories. Recently changed to 9-Vinyl PG vaginal hydrophilic gel, significantly improve the bioavailability of drugs, the amount of medication is reduced accordingly. RU_ (486), an antiprogestin, competes with progesterone at the receptor level and, after oral administration, can sensitize the myometrium to prostaglandins. It is known to be used in combination with prostaglandins to successfully terminate early pregnancies. Is the use of RU486 during labor induction of labor can shorten the drainage time, reduce side effects to study.