长期以来,癫痫的药物治疗都是凭经验的,通常用的所谓“标准”剂量主要是基于临床有效和出现毒性反应两者之间的粗略估计,未能揭示药物代谢在病人个体间的很大差异性。对于药物代谢快的人,“标准”剂量可使治疗失败;相反,对于解毒和排泄缓慢者,“标准”剂量又可产生中毒症状。加之有些抗癫痫药物(AED)如苯妥英纳(DPH)的有效和中毒剂量十分接近,常规剂量对某些病人的治疗往往不够理 Pharmacological treatments for epilepsy have long been based on experience and the so-called “standard” doses commonly used are based largely on rough estimates between clinically valid and toxic responses and fail to reveal the large magnitude of drug metabolism among individual patients difference. For people who metabolize quickly, the “standard” dose fails the treatment; conversely, the “standard” dose can cause symptoms of poisoning for those who detoxify and excrete slowly. In addition, the effective and toxic doses of some anti-epileptic drugs (AEDs) such as phenytoin (DPH) are very close, and conventional dosages tend to be inadequate for some patients