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目的:观察蛤蚧(GJ)对S180荷瘤小鼠Th1/Th2细胞因子的影响。方法:采用S180瘤株皮下接种昆明种小鼠造荷瘤模型。设正常组、模型组、环磷酰胺组(CTX),GJ高、中、低剂量组。给药14天后,计算抑瘤率、免疫器官指数;酶联免疫吸附法检测Th1类细胞因子(IL-2、IFN-γ)、Th2类细胞因子(IL-4、IL-10)的表达及计算Th1/Th2比值。结果:①与模型组比较,GJ低剂量组肿瘤生长明显受到抑制(P<0.05);②与CTX比较,GJ低剂量组脾脏指数明显升高(P<0.05),GJ中、高剂量组胸腺指数明显升高(P<0.05);③与模型组比较,GJ低剂量组IFN-γ、IL-2含量升高(P<0.05),低、中剂量组IL-4含量明显降低(P<0.05),GJ各剂量组IL-10含量降低,差异无统计学意义(P>0.05);④GJ低剂量组IFN-γ/IL-4比值、IL-2/IL-4比值均高于模型组(P<0.05)。结论:GJ可有效纠正荷瘤小鼠Th1/Th2失衡,增强机体的抗肿瘤免疫功能。
Objective: To observe the effect of Gekko geckis (GJ) on Th1 / Th2 cytokines in S180 tumor-bearing mice. Methods: Kunming mice were subcutaneously inoculated with S180 tumor-bearing mice to establish a tumor-bearing model. The normal group, model group, cyclophosphamide group (CTX), GJ high, medium and low dose group. The tumor inhibition rate and immune organ index were calculated 14 days after administration. The expression of Th1 cytokines (IL-2, IFN-γ) and Th2 cytokines (IL-4, IL-10) were detected by enzyme-linked immunosorbent assay Th1 / Th2 ratio was calculated. Results: ①Compared with model group, the growth of low dose GJ group was significantly inhibited (P <0.05); ② Compared with CTX, the spleen index of GJ low dose group was significantly increased (P <0.05) (P <0.05). Compared with the model group, the levels of IL-4 and IFN-γ in the GJ low dose group were significantly increased (P < 0.05). The levels of IFN-γ / IL-4 and IL-2 / IL-4 in GJ low dose group were significantly higher than those in model group (P <0.05). Conclusion: GJ can effectively correct the imbalance of Th1 / Th2 in tumor-bearing mice and enhance the anti-tumor immune function.