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目的研究糖尿病患者血清可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)、单核细胞趋化蛋白-1(MCP-1)和肿瘤坏死因子-α(TNF-α)水平与颈动脉粥样硬化程度的关系。方法 2型糖尿病患者108例根据颈动脉彩色多普勒超声检查结果分为颈动脉正常组(19例)、颈动脉内膜增厚组(38例)、稳定斑块组(34例)、颈动脉狭窄组(17例)。采用酶联免疫吸附法测定各组血清sICAM-1、sVCAM-1、MCP-1和TNF-α水平,分析颈动脉硬化程度与血清炎性因子水平的关系。结果血清sICAM-1、sVCAM-1、MCP-1和TNF-α水平随着颈动脉硬化程度的增加而升高,各组指标比较均有统计学差异(P<0.05)。颈动脉粥样硬化程度与血清sICAM-1、sVCAM-1、MCP-1和TNF-α水平均呈显著正相关(r=0.675,P<0.01;r=0.693,P<0.01;r=0.723,P<0.01;r=0.851,P<0.01)。另外,各炎性因子之间呈正相关。结论 2型糖尿病患者外周血中炎性因子水平可以在一定程度上反映患者的颈动脉粥样硬化程度。
Objective To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), monocyte chemoattractant protein- 1 (MCP-1) and tumor necrosis factor- (TNF-α) levels and the relationship between carotid atherosclerosis. Methods One hundred and eight patients with type 2 diabetes mellitus were divided into carotid artery normal group (19 cases), carotid intimal thickening group (38 cases), stable plaque group (34 cases), cervical Artery stenosis group (17 cases). Serum levels of sICAM-1, sVCAM-1, MCP-1 and TNF-α were measured by enzyme-linked immunosorbent assay. The relationship between carotid atherosclerosis and serum levels of inflammatory cytokines was analyzed. Results Serum levels of sICAM-1, sVCAM-1, MCP-1 and TNF-α increased with the increase of carotid atherosclerosis. The indexes in each group were significantly different (P <0.05). The level of carotid atherosclerosis was positively correlated with serum sICAM-1, sVCAM-1, MCP-1 and TNF-α levels (r = 0.675, P <0.01; r = 0.693, P <0.01; r = 0.851, P <0.01). In addition, there is a positive correlation between each inflammatory factor. Conclusion The levels of inflammatory cytokines in peripheral blood of type 2 diabetic patients can reflect the extent of carotid atherosclerosis to a certain extent.