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胃粘液－碳酸氢盐屏障是胃粘膜自身保护作用的重要机制之一。小柴胡汤及香砂六君子汤十二指肠给药１０ｇ／ｋｇ，可显著增加大鼠胃壁结合阿利新蓝量，显示促进胃粘液分泌作用。利用大鼠在体胃灌流装置，在奥美拉唑抑制大鼠胃酸分泌后，根据灌流液ｐＨ变化测定ＨＣＯ３分泌。胃内酸化（ｐＨ４．０）及静脉注射ＰＧＥ２ ６００μｇ／ｋｇ均能促进ＨＣＯ３分泌。小柴胡汤及香砂六君子汤水煎液胃内注射或十二指肠注射１０ｇ／ｋｇ，均未显示有促进ＨＣＯ３分泌作用。离休草蛙胃粘膜实验也未观察到二方有促进ＨＣＯ３分泌作用。
Gastric mucus-bicarbonate barrier is one of the important mechanisms of gastric mucosa’s own protective effect. Xiao Chaihu Decoction and Xiangsha Liujunzi Decoction were administered at a dose of 10g/kg in the duodenum, which could significantly increase the amount of alixin blue bound to the stomach wall of the rat, indicating that gastric mucus secretion was promoted. Using rat gastric perfusion device in the body, after omeprazole inhibited gastric acid secretion in rats, the secretion of HCO3 was measured according to the change of perfusate pH. Intragastric acidification (pH 4.0) and intravenous injection of PGE2 600 μg/kg promoted HCO3 secretion. Intragastric injection of Xiaochaihu Decoction and Xiangsha Liujunzi decoction decoction or duodenal injection of 10g/kg did not appear to promote HCO3 secretion. The gastric mucosa of reed frogs was also not observed to promote HCO3 secretion.