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目的 观察肺癌患者红细胞免疫功能变化 ,探讨红细胞免疫功能异常在肺癌发生中的作用。方法 采用刘景田改进的微量全血法检测 45例肺癌患者的红细胞免疫功能 ,并与 37例正常人对照分析。结果 肺癌患者红细胞C3b受体花环率 (RCR) ,红细胞C3b受体花环促进率 (RFER) ,自然肿瘤红细胞免疫花环率 (NTER)和直向肿瘤红细胞免疫花环率 (DTER)明显低于正常人 (P <0 0 1) ,促肿瘤红细胞免疫花环率 (ETER) ,协同肿瘤红细胞免疫花环率 (ATER)低于正常人 (P <0 0 5 ) ,而红细胞免疫复合物花环率 (RICR)和红细胞C3b受体花环抑制率 (RFIR)则明显高于正常人(P <0 0 1)。结论 肺癌患者红细胞免疫功能低下 ,检测其红细胞免疫功能有助于肺癌的诊断和治疗
Objective To observe the changes of erythrocyte immune function in patients with lung cancer and to explore the role of erythrocyte immune dysfunction in the occurrence of lung cancer. Methods 45 cases of lung cancer were tested for erythrocyte immune function by modified micro-whole blood method of Liu Jingtian and compared with 37 normal controls. Results The RBC, RFER, NTER and DTE of erythrocyte C3b receptor in lung cancer patients were significantly lower than those in normal controls (P <0.01). The rate of erythrocyte immunization rosette (ETER) and synergistic tumor erythrocyte immunization rosette rate (ATER) was lower than that of normal people (P <0 05). The ratio of erythrocyte immune complex rosette (RICR) C3b receptor rosette inhibition rate (RFIR) was significantly higher than normal (P <0.01). Conclusions Patients with lung cancer have poor erythrocyte immune function and the detection of erythrocyte immune function is helpful for the diagnosis and treatment of lung cancer