人Endostatin基因的腺病毒表达载体治疗鼻咽癌,可以明显地减小肿瘤体积,Ⅰ期临床试验已经开始。Endostatin基因表达也可以抑制血管生成。中国中山大学癌症中心的黄文林教授说:“抗血管生成治疗可能成为鼻咽癌综合治疗的手段之一。”先前的工作已经显示,肿瘤增殖依靠血管的生成。在肿瘤生长时,自身需要新生血管供应血液,否则细胞将死亡。Endostatin抑制新生血管的增殖和内皮细胞的 Endostatin gene adenovirus expression vector for the treatment of nasopharyngeal carcinoma, can significantly reduce the tumor size, phase Ⅰ clinical trials have begun. Endostatin gene expression can also inhibit angiogenesis. Professor Huang Wenlin from the Cancer Center of Sun Yat-sen University in China said: “Anti-angiogenic therapy may be one of the tools for the comprehensive treatment of nasopharyngeal carcinoma.” Previous work has shown that tumor proliferation depends on the formation of blood vessels. When tumors grow, they themselves need new blood vessels to supply the blood, otherwise the cells will die. Endostatin inhibits neovascularization and endothelial cell proliferation