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目的观察α-硫辛酸联合依帕司他治疗2型糖尿病周围神经病变的临床疗效。方法选择2型糖尿病合并周围神经病变患者38例,均给予α-硫辛酸0.6 g静滴每日1次,依帕司他50 mg口服,每日3次,连用3周。观察患者治疗前后神经系统症状及体征变化,并测定治疗前后患者四肢的神经传导速度、膝跟腱反射以及空腹血糖、血尿常规和肝肾功能等。结果α-硫辛酸联合依帕司他治疗后,患者神经系统症状及体征变化均明显好转,各神经传导速度与治疗前相比均有显著性差异(P<均0.05)。血糖、肝肾功能、血尿常规与治疗前比较无显著性差异(P均>0.05)。结论α-硫辛酸联合依帕司他是治疗糖尿病周围神经病变安全、有效的药物。
Objective To observe the clinical efficacy of α-lipoic acid combined with epalrestat in the treatment of type 2 diabetic peripheral neuropathy. Methods Thirty-eight patients with type 2 diabetes mellitus and peripheral neuropathy were enrolled. All patients were given α-lipoic acid (0.6 g) intravenously once daily and epalrestat 50 mg orally three times a day for 3 weeks. The changes of neurological symptoms and signs before and after treatment were observed. The nerve conduction velocity, knee-Achilles tendon reflex, fasting blood glucose, hematuria, liver and kidney function were measured before and after treatment. Results After treatment with α-lipoic acid and epalrestat, the neurological symptoms and signs of the patients were significantly improved. The nerve conduction velocity was significantly different from that before treatment (P <0.05). There were no significant differences in blood glucose, liver and kidney function, and hematuria before and after treatment (all P> 0.05). Conclusion α-lipoic acid combined with epalrestat is a safe and effective drug for the treatment of diabetic peripheral neuropathy.