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Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appa rently healthy paediatric cancer survivors in order to determine their participa tion in sporting activities. Methods: A total of 84 young (< 21 years) asy- mptomatic childhood cancer survivors, who had been exposed to anthracyclines ( mean dose 212 mg/m2) and/or chest irradiation (median dose 2000 cGy), with norma l left ventricular systolic function at rest (fractional shortening > 29%), and 79 healthy controls were studied. Exercise testing was performed on a treadmill ergometer. Gas exchange analysis and derived variables were measured on a breat h-by-breath basis. Pulmonary functional evaluation was performed before exerci se. Echocardiographic evaluation at rest was performed within one month before t he exercise test. Results: There were no differences in exercise responses betwe en patients and controls. In boys < 13 years, mean VO2 max was slightly but sign ificantly lower than in controls. This finding was thought to be a result of dec reased physical fitness as all the other exercise parameters were similar to those in the controls. Conclusions: Results show that apparently healthy survivors of paediatric cancer can take part in dynamic sporting activities if they exhibi t a normal response to cardiopulmonary exercise testing, while those that exhibi t a reduced VO2 max should be re-evaluated after an aerobic training programme, and should undergo tailored dynamic physical activity if the VO2 max does not n ormalise.
Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appantly willing pediatric cancer survivors in order to determine their participation in sporting activities. Methods: A total of 84 young (<21 years) asy- mptomatic childhood cancer survivors, who had has been exposed to anthracyclines (mean dose 212 mg / m2) and / or chest irradiation (median dose 2000 cGy) with norma l left ventricular systolic function at rest (fractional shortening> 29%), and 79 healthy controls were studied. was performed on a treadmill ergometer. Gas exchange analysis and derived variables were measured on a breat h-by-breath basis. Pulmonary functional evaluation was performed before exerci se. Echocardiographic evaluation at rest was performed within one month before t he exercise test. : There were no differences in exercise responses betwe en patients and controls. In boys <13 years, mean VO2 max was slightly but sign ificantly lower than in controls. This fin ding was thought to be a result of dec reased physical fitness as all the other exercise parameters were similar to those in the controls. Conclusions: Results show that apparently healthy survivors of pediatric cancer can take part in dynamic sporting activities if they exhibi ta normal response to cardiopulmonary exercise testing, while those that exhibi ta reduced VO2 max should be re-evaluated after an aerobic training program, and should have tailored dynamic physical activity if the VO2 max does not n ormalise.