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用免疫组化ＡＢＣ方法检测了６０例卵巢囊腺肿瘤组织中增生细胞核抗原（ＰＣＮＡ）和ｐ５３蛋白的表达。结果表明：ＰＣＮＡ和ｐ５３蛋白在良性囊腺瘤、交界性囊腺瘤和囊腺癌三类不同性质的病变中表达存在显著的差别（Ｐ＜０．００１，Ｐ＜０．０５）。ｐ５３蛋白与ＰＣＮＡ表达关系密切，高增生指数（ＰＣＮＡ＋＋＋）肿瘤ｐ５３蛋白阳性率高，低增生指数肿瘤（ＰＣＮＡ＋，－）ｐ５３表达率低。认为在卵巢囊腺肿瘤中检测ＰＣＮＡ和ｐ５３蛋白的表达，有助于了解它们的生物学行为，并可能有预测预后的价值。
Immunohistochemical ABC method was used to detect the expression of proliferating cell nuclear antigen (PCNA) and p53 protein in 60 cases of ovarian cystadenocarcinoma. The results showed that the expression of PCNA and p53 protein in benign cystadenoma, borderline cystadenoma and cystadenocarcinoma were significantly different (P <0.001, P <0.05). The expression of p53 protein is closely related to the expression of PCNA. The positive rate of p53 protein in high proliferative index (PCNA +++) tumors is high, while the expression of p53 in low proliferative index tumors (PCNA +, -) is low. It is believed that the detection of PCNA and p53 protein expression in ovarian cystadenocarcinomas helps to understand their biological behavior and may have prognostic value.