目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)对Ⅱ型糖尿病发生的影响。方法 :选择OSAS患者 6 0例和正常对照组 2 0例行多导睡眠图 (PSG)检查和空腹血糖 (FPG)、餐后 2h血糖 (2HPG)、空腹胰岛素 (FINS)、空腹C -肽 (FCP)、糖化血红蛋白A1c(GHbA1c)测定。结果 :OSAS组的FPG、2HPG、GHbA1c、FINS、FCP水平均明显高于正常组 ,且OSAS病情越重 ,轻、中、重度组间差别也越显著。各组BMI、FPG、2HPG、GHbA1c、FINS、FCP及糖尿病发生率与睡眠呼吸暂停低通气指数 (AHI)、经皮血氧饱和度 (SpO2 )降低大于 0 .0 4的总次数、SpO2 低于 0 .90的时间呈显著正相关 ,而与睡眠中SpO2 最低值和平均值呈显著负相关。结论 :AHI、呼吸暂停持续时间及SpO2 降低的程度是导致OSAS患者糖耐量减低和Ⅱ型糖尿病发生的重要的因素 Objective: To investigate the effect of obstructive sleep apnea syndrome (OSAS) on type 2 diabetes. Methods: Sixty patients with OSAS and 20 normal subjects with polysomnography (PSG) and fasting plasma glucose (FPG), postprandial 2h blood glucose (2HPG), fasting insulin (FINS) and fasting C - peptide FCP), glycated hemoglobin A1c (GHbA1c). Results: The levels of FPG, 2HPG, GHbA1c, FINS and FCP in OSAS group were significantly higher than those in normal group, and the more severity of OSAS in OSAS group was. The incidences of BMI, FPG, 2HPG, GHbA1c, FINS, FCP and diabetes were significantly lower than those of sleep apnea hypopnea index (AHI) and percutaneous oxygen saturation (SpO2) 0.90 of the time was significantly positive correlation, while with sleep SpO2 lowest and mean significant negative correlation. CONCLUSIONS: AHI, the duration of apnea, and the extent of SpO2 decrease are important factors that lead to impaired glucose tolerance and type 2 diabetes in patients with OSAS