分别用左旋、右旋和消旋吡喹酮100mg/kg灌胃健康家兔,采用反相高效液相色谱法分别测定该三药在门静脉,全身循环以及胆汁中的含量。发现左旋、右旋和消旋吡喹酮均能从胃肠道迅速吸收,它们在门脉内的血药浓度相近,三药在全身循环中的血药浓度均大为减低,但其中以右旋吡喹酮下降尤为明显。左旋、右旋和消旋吡喹酮的肝内在 The healthy rabbits were perfused with 100 mg / kg praziquantel, respectively. The content of the three drugs in the portal vein, systemic circulation and bile were determined by RP-HPLC. It was found that both praziquantel and dexrazoxane could be rapidly absorbed from the gastrointestinal tract. The plasma concentrations of praziquantel in the portal vein were similar, and the plasma concentrations of the three drugs in the systemic circulation were greatly reduced. However, The reduction of praziquantel is particularly evident. Left, right and racemic praziquantel intrahepatic