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脑血管病是威胁人类健康和致残致死的常见多发病,且随着年龄增长而呈上升的趋势。当前实验脑缺血研究存在的主要问题;(1)大多数实验性脑缺血多采用啮齿类动物开颅结扎其脑血管而复制,发病环节与临床差距甚远;(2)由于多为预防性给药,不利于“时间音”选择的研究;(3)缺血半暗区的划分因梗塞区不固定而难以获得较客观的观察指标,以致拯救半暗区的进展不大。因此采用接近于人类发病条件的模型及生物学特性与人相似的动物研究脑缺血具有重要的实践意义、光化学诱导树血栓性局部脑缺血乃继发于血管内皮细胞受损、血栓形成所致的脑缺血,组织化学染色可见梗塞面积与光照范围一致,其缺血半略区局部脑血流(rCBF)减少(为37.58±169%,P<0.01)、神经元Na+、Ca2+增多(分别为433.0±87.2μmol/g和32.3±1.74μmol/g,P<0.01)以及水含量(密度梯度法)增加(为82.41±0.78%,P<0.01)的改变不及中心区严重,但明显高于对侧区(P均<0.01)。实验后4h上述各项指标的改变是血管内血小板聚集、血栓形成阻塞血管以及多种活性物质相互作用的结果。缺血中心区去甲肾上腺素(NA)、多巴胺(DA)、5-羟色胺?
Cerebrovascular disease is a common and frequently-occurring disease that threatens human health and disability, and it tends to rise with age. (1) Most of the experimental cerebral ischemia using rodents craniotomy ligation of its cerebrovascular and replication, the pathogenesis and clinical far away; (2) due to the more prevention Sexual administration, is not conducive to the study of the choice of “time tone”; (3) the division of the ischemic penumbra area due to the infarction area is not fixed and it is difficult to obtain more objective observations, resulting in little progress in the rescue of the penumbral area. Therefore, it is of important practical significance to study cerebral ischemia using a model similar to that of human and the biological characteristics of the animal. Photochemical-induced thrombotic cerebral ischemia is secondary to vascular endothelial cell damage, thrombosis (RCBF) decreased (37.58 ± 169%, P <0.01), while the area of Na + , Ca2 + increased (433.0 ± 87.2μmol / g and 32.3 ± 1.74μmol / g respectively, P <0.01) and water content increased by density gradient method (82.41 ± 0.78 %, P <0.01) were less severe than those in the central region, but significantly higher than those in the contralateral region (all P <0.01). 4h after the experiment the above indicators of change is the result of intravascular platelet aggregation, blood clots thrombosis and the interaction of a variety of active substances. Ischemic center norepinephrine (NA), dopamine (DA), serotonin?