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应用定量放射自显影技术，以氚标配体MK－801、AMPA和KA分别标记NMDA、AMPA和KA受体，定量观察了七种近交系小鼠海马结构内兴奋性氨基酸受体的区域分布类型和受体密度变化．结果表明，海马CA1区含有高密度NMDA和AMPA受体，CA3和齿状回含高密度KA受体。三种受体在海马各区的分布类型无明显系间差异，而其受体密度存在着明显的系间差别。NMDA和AMPA受体在BALB.c鼠海马显示最高密度，而CPB-K鼠以上两种受作密度最低。KA受体在NMRI鼠海马显示最高密度，BA鼠其受体密度最低．这种受体密度的系间差异可能与近交系小鼠合成兴奋性氨基酸受体的基因调控不同有关。
The regional distribution of excitatory amino acid receptors in the hippocampal formation of seven inbred mice was quantitatively observed by using the tritium labeled ligand MK-801, AMPA and KA, respectively, by using quantitative autoradiography Type and receptor density changes. The results showed that hippocampal CA1 region contains high density NMDA and AMPA receptors, CA3 and dentate gyrus containing high density KA receptors. The distribution of three receptors in the hippocampus was not significantly different between the lines, and its receptor density there is a significant line between the differences. NMDA and AMPA receptors showed the highest density in the BALB.c mouse hippocampus, while CPB-K mice received the lowest density in both. KA receptors showed the highest density in NMRI rat hippocampus, and BA rats had the lowest receptor density. The differences in this receptor density may be related to the different gene regulation of the excitatory amino acid receptors in inbred mice.