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目的:探讨血小板生长因子在妊高征发病中的作用,进一步阐明妊高征发病机制。方法:运用酶联免疫吸附法测定30例妊高征患者(妊高征组,其中轻度10例,中重度20例)、13例正常晚孕妇女(正常晚孕组)血清中血小板生长因子含量。结果:血小板生长因子含量在正常晚孕组为(39.61±18.20)pg/ml,在轻度妊高征组为(49.48±25.40)pg/ml,在中重度妊高征组为(83.54±34.52)pg/ml。正常晚孕组与轻度妊高征组比较,差异无显著性(P>0.05);正常晚孕组与中重度妊高征组比较,差异有极显著性(P<0.001);轻度妊高征与中重度妊高征组比较,差异有显著性(P<0.05)。结论:妊高征患者血清中血小板生长因子含量变化与妊高征发病及病情的严重程度有关。
Objective: To investigate the role of platelet-derived growth factor in the pathogenesis of PIH and further elucidate the pathogenesis of PIH. Methods: Serum levels of platelet-derived growth factor (IGF-1) in 30 patients with PIH (mild PIH, 20 mild PIH, 20 moderate PIH) and 13 normal pregnant women (normal pregnancy group) were measured by enzyme-linked immunosorbent assay content. Results: The levels of platelet growth factor were (39.61 ± 18.20) pg / ml in normal pregnancy group, (49.48 ± 25.40) pg / ml in mild pregnancy induced hypertension group and 83.54 ± 34.52 ) pg / ml. There was no significant difference between normal pregnancy group and mild pregnancy induced hypertension group (P> 0.05). There was significant difference between normal pregnancy group and moderate-severe pregnancy-induced hypertension group (P <0.001) There was a significant difference between high-exacerbation and moderate-severe preeclampsia (P <0.05). Conclusion: The changes of serum platelet growth factor in patients with PIH are related to the incidence of PIH and the severity of the disease.