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目的:探讨双歧杆菌三联活菌散对婴幼儿轮状病毒性肠炎患儿血清炎症因子的影响及疗效。方法:74例婴幼儿轮状病毒性肠炎患儿随机分为观察组(37例)和对照组(37例)。两组患儿均予调整饮食、抗病毒、补液及预防和纠正电解质紊乱和酸碱失衡等常规治疗。观察组加用双歧杆菌三联活菌散温水冲服,连用72 h。观察两组患儿治疗前后血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平变化,比较两组临床疗效及药品不良反应。结果:治疗72h后,两组患儿血清IL-6和TNF-α水平均较前明显下降(P<0.05或P<0.01),且观察组水平明显低于对照组(P<0.05)。观察组临床总有效率明显高于对照组(P<0.05)。两组患儿治疗期间未见药品不良反应。结论:双歧杆菌三联活菌散治疗婴幼儿轮状病毒性肠炎疗效显著,可能与明显降低血清IL-6和TNF-α水平,控制肠黏膜炎症反应,且安全性高。
Objective: To investigate the effect of triple Bifidobacterium of Bifidobacterium on serum inflammatory factors in infants with rotavirus enteritis. Methods: Totally 74 infants with rotavirus enteritis were randomly divided into observation group (37 cases) and control group (37 cases). Two groups of children are to be adjusted diet, antiviral, rehydration and prevention and correction of electrolyte imbalance and acid-base imbalance and other conventional treatment. The observation group plus bifidobacterium triple living bacteria scattered warm water blunt, once every 72 hours. The levels of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were observed before and after treatment. The clinical efficacy and adverse drug reactions were compared between the two groups. Results: After 72 hours of treatment, the levels of IL-6 and TNF-α in both groups were significantly lower than those before (P <0.05 or P <0.01), and the levels in the observation group were significantly lower than those in the control group (P <0.05). The total effective rate in observation group was significantly higher than that in control group (P <0.05). Two groups of children with no adverse drug reactions during treatment. Conclusion: Bifidobacterium triple viable powder treatment of infantile rotavirus enteritis significant effect, may be associated with significantly lower serum levels of IL-6 and TNF-α, control of inflammatory reaction of the intestinal mucosa, and high safety.