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目的:探讨宫颈糜烂程度与宫颈上皮内瘤变(CIN)和宫颈癌变的关系。方法:将本院2010年5月-2011年5月收治的300例不同程度的宫颈糜烂患者作为研究对象,根据病变程度分为轻度糜烂、中度糜烂和重度糜烂三组。同时选取同期宫颈光滑妇女100例作为对照组。聚合酶链反应法检测子宫颈癌、宫颈上皮内瘤样病变的表达,比较各组CIN和宫颈癌的疾病构成比。结果:各组无病变,CIN Ⅰ、CIN Ⅱ、CIN Ⅲ及宫颈癌的疾病构成比分别为对照组(宫颈光滑组):86.0%、6.00%、5.00%、2.00%、1.00;轻度糜烂组:81.63%、7.15%、6.12%、4.08%、1.02%;中度糜烂组:83.33%、5.88%、4.90%、3.92%、1.96;重度糜烂组:84.00%、7.00%、4.00%、4.00%、1.00%。轻重中各组之间的疾病构成比较,差异无统计学意义(P<0.05)。无糜烂组CIN和宫颈癌的构成比明显高于糜烂组。结论:与宫颈糜烂相比,CIN的发生并未增加宫颈癌的发病率,糜烂程度与癌变之间无明显相关性,不能作为诊断宫颈癌的高危因素和标准。
Objective: To investigate the relationship between cervical erosion and cervical intraepithelial neoplasia (CIN) and cervical carcinogenesis. Methods: From May 2010 to May 2011 in our hospital, 300 cases of cervical erosion patients with different degrees were studied. According to the degree of lesion, they were divided into three groups: mild erosion, moderate erosion and severe erosion. At the same time, 100 cases of cervical smooth women were selected as the control group. The expressions of cervical intraepithelial neoplasia and cervical intraepithelial neoplasia were detected by polymerase chain reaction (PCR) and the ratio of CIN to cervical cancer in each group was compared. Results: The disease proportions of CIN Ⅰ, CIN Ⅱ, CIN Ⅲ and cervical cancer were 86.0%, 6.00%, 5.00%, 2.00%, 1.00 in the control group and mild cervical erosion group Moderate erosion group: 83.33%, 5.88%, 4.90%, 3.92%, 1.96; severe erosion group: 84.00%, 7.00%, 4.00%, 4.00% , 1.00%. The severity of the disease composition between the groups, the difference was not statistically significant (P <0.05). No erosion group CIN and cervical cancer was significantly higher than the erosion group. Conclusion: Compared with cervical erosion, the incidence of cervical cancer does not increase the incidence of cervical cancer, the degree of erosion and cancer had no significant correlation between the risk of cervical cancer can not be used as a diagnostic criteria and risk factors.