论文部分内容阅读
目的对比分析三维适形放疗(3DCRT)、调强放疗(IMRT)以及常规放疗对食管癌的疗效。方法本研究选择我院2006年1月至2012年8月期间收治的78例食管癌患者为研究对象,将其随机分为A、B、C三组,A组26例行常规放疗,B组26例行3DCRT放疗,C组26例行IMRT放疗,对比分析三种放疗方式的疗效以及不良反应。结果 A、B、C三组患者经过放疗后有效率基本一致,比较差异不具有统计学意义(P>0.05),3组患者1、2年生存率比较差异不具有统计学意义(P>0.05);B组+C组总疼痛缓解率高于A组,但比较差异不具有统计学意义(P>0.05);B组+C组经放射治疗后放射性食管炎发生率明显高于A组(P<0.05),放射性肺炎、气管炎发生率和骨髓抑制明显低于A组(P<0.05)。结论 3DCRT和IMRT放疗于常规放疗近期疗效基本一致,但其能有效的减轻患者放疗后放射性损伤,提高临床治疗效果,值得在临床上广泛的推广和应用。
Objective To compare and analyze the curative effect of three-dimensional conformal radiotherapy (3DCRT), IMRT and conventional radiotherapy on esophageal cancer. Methods A total of 78 patients with esophageal cancer admitted to our hospital from January 2006 to August 2012 were enrolled in this study. They were randomly divided into three groups: A, B and C, and 26 patients in group A underwent conventional radiotherapy. Group B 26 cases received 3DCRT radiotherapy and 26 cases C group received IMRT radiotherapy. The curative effects and adverse reactions of the three radiotherapy methods were compared and analyzed. Results The effective rates of group A, B and C after radiotherapy were basically the same, but the difference was not statistically significant (P> 0.05). The 1 and 2 year survival rates of the 3 groups were not statistically significant (P> 0.05 ); The total pain relief rate in group B + C was higher than that in group A, but the difference was not statistically significant (P> 0.05); The incidence of radiation esophagitis in group B + C was significantly higher than that in group A P <0.05). Radiation pneumonitis, bronchitis incidence and bone marrow suppression were significantly lower than those in group A (P <0.05). Conclusion The 3DCRT and IMRT radiotherapy have the same curative effect in the conventional radiotherapy. However, they can effectively reduce the radiological damage after radiotherapy and improve the clinical curative effect. It is worth widely popularized and applied in clinic.