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贝特类药物是临床广泛应用的降脂药,因其显著降低甘油三酯水平,常被用于治疗高甘油三酯血症和混合型高脂血症,从而实现抗动脉粥样硬化和预防心血管事件的目的。大量研究报告表明,临床应用贝特类药物能够导致以横纹肌溶解症为代表的肌肉毒性,严重者甚至死亡。本文对贝特类药物肌肉毒性机制的研究进展作以综述,为指导临床用药和毒性机制研究提供参考。
Beit class is widely used in clinical lipid-lowering drugs, because of its significant lower triglyceride levels, often used to treat hypertriglyceridemia and mixed hyperlipidemia, in order to achieve anti-atherosclerosis and prevention The purpose of the cardiovascular event. A large number of studies have shown that clinical application of fibrates can cause muscular toxicity represented by rhabdomyolysis, severe cases and even death. This review summarizes the research progress on the mechanism of fibrate toxicity in fibrates, and provides reference for the study of clinical drug use and toxicity mechanism.