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目的:研究不孕女性中衣原体(chlamydia trachomatis,CT)感染与抗精子抗体(antisperm antibody,As-Ab)之间的关系。方法:选择2004年2月~2006年2月在计划生育指导所生殖医学门诊就诊的不孕女性370例,其中原发不孕120例(原发不孕组),继发不孕250例(继发不孕组),同时选择健康已孕女性100例作为对照(对照组)。应用衣原体一步免疫层析法检测CT感染,酶联免疫吸附法检测血清中AsAb。结果:不孕组CT感染率、AsAb阳性率与对照组比较差异均有统计学意义(P<0.05);继发不孕组CT感染率、AsAb阳性率与原发不孕组比较差异无统计学意义(P>0.05);不孕组中AsAb阳性患者CT感染率与阴性患者比较差异有统计学意义(P<0.05)。结论:CT感染及AsAb均可造成女性不孕,AsAb的产生与CT感染有关。
Objective: To study the relationship between infection of chlamydia trachomatis (CT) and antisperm antibody (As-Ab) in infertile women. Methods: A total of 370 infertile women were enrolled in the Reproductive Medicine Clinic of Family Planning Institute from February 2004 to February 2006, including 120 cases of primary infertility (primary infertility group), 250 cases of secondary infertility Secondary infertility group), while 100 healthy pregnant women were selected as a control (control group). Chlamydia trachomatis by one-step immunochromatography CT infection was detected by enzyme-linked immunosorbent assay serum AsAb. Results: The CT infection rate and AsAb positive rate in infertility group were significantly different from those in control group (P <0.05). There was no significant difference in CT infection rate and AsAb positive rate between infertility group and primary infertility group (P> 0.05). There was significant difference in CT infection rate between AsAb-positive patients and negative patients in infertility group (P <0.05). Conclusion: Both CT and AsAb can cause infertility in women. AsAb production is related to CT infection.