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目的了解宣城市药物不良反应(ADR)的来源、类别、表现和特点,ADR涉及药物种类、剂型、给药途径和风险等,以减少和避免ADR的发生。方法通过国家ADR监测系统平台,导出2015年宣城市上报的ADR监测报告,共计3280例,对ADR进行分析。结果 3280例ADR报告中,化学药物及抗感染药物2810例(85.7%),其他类别药物470例(14.3%);严重ADR排名前5位的药物为左氧氟沙星注射液、克林霉素注射液、参麦注射液、头孢曲松粉针剂和清开灵注射液;ADR损伤临床表现前5位是胃肠系统损伤、皮肤及其附件损伤、中枢及外周神经系统损伤、全身性损伤和呼吸系统损伤。结论涉药人员尤其是临床医护人员应协同药师做好ADR监测报告,规避用药风险,促进安全合理用药。
Objective To understand the origin, category, performance and characteristics of Adverse Drug Reaction (ADR) in Xuancheng City. ADR involved in drug type, dosage form, route of administration, risk and so on, in order to reduce and avoid the occurrence of ADR. Methods The ADR monitoring report submitted by Xuancheng in 2015 was derived from the platform of National ADR Monitoring System. A total of 3280 cases were reported, and ADR was analyzed. Results Among the 3280 ADR cases, 2810 (85.7%) were chemical and anti-infectives and 470 (14.3%) were other kinds of drugs. The top 5 ADRs were levofloxacin, clindamycin, Shenmai injection, ceftriaxone injection and Qingkailing injection. The top five clinical manifestations of ADR injury were gastrointestinal injury, skin and accessory injury, central and peripheral nervous system injury, generalized injury and respiratory injury . Conclusion The drug-related personnel, especially the clinicians, should work together with the pharmacists to do ADR monitoring reports to avoid the risk of medication and promote safe and rational drug use.