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目的:探讨河南食管癌高发区反流性食管炎(RE)患者食管上皮组织病理变化的特征。方法:对临床内镜诊断的86例RE患者及61例正常对照的食管黏膜活检组织进行组织病理学观察。结果:RE患者食管上皮基底细胞过度增生、间变、乳头升高发生率分别为64%(55/86)、20%(17/86)和76%(65/86),高于对照组的30%(18/61)、0(0/61)和20%(12/61)(P均<0.05);RE组乳头密度(3.7±2.8)个/mm,高于对照组的(1.2±1.0)个/mm(t=8.28,P<0.05)。结论:基底细胞过度增生、间变、固有膜乳头升高和增生是河南食管癌高发区RE患者的基本病理改变。
Objective: To investigate the pathological changes of esophageal epithelium in patients with reflux esophagitis (RE) in high incidence area of esophageal cancer in Henan province. Methods: The histopathological changes of 86 esophageal mucosal biopsy specimens from 86 RE patients and 61 normal controls were observed by endoscopy. Results: The rates of esophageal epithelial basal cell hyperplasia, anaplastic and papillary elevation in RE patients were 64% (55/86), 20% (17/86) and 76% (65/86) respectively, which were significantly higher than those in control group (3.7 ± 2.8) mm / mm in RE group were significantly higher than those in control group (1.2 ± 0.3%, P <0.05) 1.0) pieces / mm (t = 8.28, P <0.05). CONCLUSION: Basal cell hyperplasia, anaplastic and membranous papillae hyperplasia are the basic pathological changes in RE patients with high incidence of esophageal cancer in Henan Province.