论文部分内容阅读
葡萄糖耐量低减患者并发心、脑等大血管疾病的发病率明显高于糖耐量正常人群,甚至与糖尿病人群接近,严重威胁该人群的健康和生存质量。其中,胰岛素抵抗是葡萄糖耐量低减患者容易发生早期大血管病变的中心环节,并可通过多种机制,引发餐后高血糖、炎性反应、高血脂等,直接或间接地损伤血管内皮及其功能,导致血管病变的发生和发展。
Patients with impaired glucose tolerance and cardiovascular and cerebrovascular complications were significantly higher than those with normal glucose tolerance and even with diabetes, which seriously threatened the health and quality of life of the population. Among them, insulin resistance is the central part of early macrovascular disease in patients with impaired glucose tolerance, and can directly or indirectly damage the vascular endothelium through multiple mechanisms such as postprandial hyperglycemia, inflammatory reaction, hyperlipidemia and the like Function, leading to the occurrence and development of vascular lesions.