中国医学科学院药物研究所和中国科学院生物物理研究所的一项合作成果,报告了关于新颖芳香类化合物异戊烯基转移酶-AtaPT的新进展,揭示了其杂泛性的分子机制,展现了该酶在药用活性化合物生物合成与天然药物合成生物学方面的巨大应用前景。成果12月19日在线发表于《自然-化学生物学》。传统上,酶被认为具有严格的底物及反应特异性,然而,研究发现许多酶却能催化不同于 A collaboration between the Institute of Materia Medica, Chinese Academy of Medical Sciences and the Institute of Biophysics, Chinese Academy of Sciences, reports on recent advances in the novel isopentenyl transferase-AtaPT, revealing the molecular mechanism of its heterogeneity, The enzyme has great potential applications in the biosynthesis of pharmaceutical active compounds and the biosynthesis of natural medicines. Results December 19 online published in “Nature - Chemical Biology.” Traditionally, enzymes are thought to have stringent substrate and reaction specificity; however, many studies have found that enzymes catalyze different