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目的探讨血清胱抑素C(CysC)在冠心病患者中的变化及其与冠状动脉硬化程度的关系。方法选取因胸痛初诊入院并行冠脉造影诊断为冠心病的患者80例,另选择体检健康者30例作为对照组,分别测定两组血清中胱抑素C水平,对其进行分析,并通过Gensini评分系统对冠状动脉病变进行评分。结果 CHD组的CysC值较对照组高,差异有统计学意义(P<0.05);血清胱抑素C水平与Gensini评分呈正相关(r=0.268,P<0.01)。结论检测血清胱抑素C水平在冠心病诊断及预测冠状动脉病变严重程度等方面具有重要意义。
Objective To investigate the changes of serum cystatin C (CysC) in patients with coronary heart disease and its relationship with the severity of coronary atherosclerosis. Methods Eighty patients diagnosed as CHD by chest pain and coronary angiography were selected. 30 healthy people were selected as the control group. Serum levels of Cystatin C were measured and analyzed by Gensini Scoring system for coronary artery disease score. Results The CysC value in CHD group was significantly higher than that in control group (P <0.05). Serum cystatin C level was positively correlated with Gensini score (r = 0.268, P <0.01). Conclusion The detection of serum cystatin C is of great significance in the diagnosis of coronary heart disease and the prediction of the severity of coronary artery disease.