论文部分内容阅读
抗抑郁新药奈法唑酮是一种苯哌嗪类化合物，具有抑制５ＨＴ再摄取和拮抗５ＨＴ２受体作用。口服吸收良好，主要产生ｍＣＰＰ，ＨＯＮＥＦ，ＰＨＯＮＥＦ３种代谢物，半衰期为２～５ｈ，大部分经粪便排泄。奈法唑酮具良好的抗抑郁效果，与丙咪嗪相当。副反应较丙咪嗪、氟西汀轻。对胆碱能受体、组胺受体几乎无亲和作用。对α１肾上腺素受体亲和性很低。不产生心脏毒性作用及性功能障碍，常见副反应有口干、嗜睡、头晕、恶心、便秘和视力模糊。
Nyfazodone, an antidepressant drug, is a pipiazine compound that inhibits 5-HT reuptake and antagonizes 5-HT2 receptor. Oral absorption of good, mainly produced mCPP, HO NEF, P HO NEF 3 kinds of metabolites, half-life of 2 ~ 5h, most of excreted by the feces. Nefazodone has a good antidepressant effect, comparable with imipramine. Side effects than imipramine, fluoxetine light. On cholinergic receptors, histamine receptors almost no affinity. Alpha 1 adrenergic receptor affinity is low. Does not produce cardiotoxic effects and sexual dysfunction, common side effects are dry mouth, drowsiness, dizziness, nausea, constipation and blurred vision.