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目的探讨非酒精性脂肪性肝病(NAFLD)患者血脂、血液流变学变化及其临床意义。方法检测107例NAFLD患者(A组)和95例健康人(C组)血清肝酶、血脂和血液流变学指标。结果 A组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(γ-GT)、葡萄糖(Glu)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、全血黏度(高、中、低切)、血浆黏度、血细胞比容(Hct)、血浆纤维蛋白原(Flb)、血沉方程K值(ESR-K)、红细胞聚集指数(EGI)均明显高于C组(P<0.05或P<0.01),而高密度脂蛋白胆固醇(HDL-C)明显低于C组(P<0.05)。结论对NAFLD患者定期血脂、血液流变学检测能反映体内脂质代谢状况,对观察病情和评估预后都有一定的价值。
Objective To investigate the changes of blood lipid and hemorheology in patients with non-alcoholic fatty liver disease (NAFLD) and its clinical significance. Methods Serum enzymes, lipids and hemorheology were detected in 107 NAFLD patients (group A) and 95 healthy people (group C). Results A group of patients with ALT, AST, γ-GT, Glu, TC, (TG), low density lipoprotein cholesterol (LDL-C), whole blood viscosity (high, medium and low cut), plasma viscosity, hematocrit (Hct), plasma fibrinogen (Flb) (ESR-K) and erythrocyte aggregation index (EGI) were significantly higher than those in group C (P <0.05 or P <0.01), while HDL-C was significantly lower than that in group C . Conclusion Regular lipid profile and hemorheological test in patients with NAFLD can reflect the lipid metabolism status in vivo, which is of value in observing the disease and evaluating the prognosis.