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目的 了解细胞间粘附分子 1(intercellularadhensionmolecule 1,ICAM 1)在哮喘患儿气道炎症中的作用。方法 通过纤维支气管镜活检气道粘膜 ,分别进行病理、免疫组织化学及原位杂交检查 ,观察气道粘膜炎症和ICAM 1及其mRNA在哮喘患儿气道上皮细胞的表达 ,并与对照儿童比较。结果 哮喘患儿存在气道粘膜炎症 ,ICAM 1及其mRNA在哮喘患儿气道上皮细胞的表达增加。结论 ICAM 1在哮喘患儿气道上皮细胞的高表达与气道炎症有关
Objective To investigate the role of intercellular adhesion molecule 1 (ICAM 1) in airway inflammation in asthmatic children. Methods The airway mucosa were biopsied by fiberoptic bronchoscopy. The pathological, immunohistochemical and in situ hybridization tests were performed respectively. The airway mucosal inflammation and expression of ICAM 1 and its mRNA in airway epithelial cells of asthmatic children were observed and compared with control children . Results There was airway mucosal inflammation in children with asthma, and the expression of ICAM 1 and its mRNA in airway epithelial cells of asthmatic children increased. Conclusion The high expression of ICAM-1 in airway epithelial cells of children with asthma is related to airway inflammation