1997年,P8基因首先从鼠胰腺炎模型中被克隆并测序[1],1999年,Ree等[2]发现一个可能与乳腺癌转移有关的基因,并将其命名为转移候选基因1(candidate of metastasis-1,com-1)。com-1是鼠P8的人类对应基因,由于此基因具有核定位信号(NLS),提示是一种核蛋白,因此被称为核蛋白1(nuclear protein 1,Nupr1)。Nupr1具有转录活性,可通过参与不同的胞内信号途径来发挥不同的功 In 1997, the P8 gene was first cloned and sequenced from the murine pancreatitis model [1]. In 1999, Ree et al [2] found a gene that may be involved in breast cancer metastasis and named it candidate gene candidate 1 of metastasis-1, com-1). com-1, a human counterpart of murine P8, is known as nuclear protein 1 (Nupr1) because of its nuclear localization signal (NLS), suggesting a nuclear protein. Nupr1 is transcriptionally active and can exert different functions by participating in different intracellular signaling pathways