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目的:观察单独使用酮康唑治疗和酮康唑联合克霉唑栓治疗高龄念球菌性阴道炎的效果。方法:根据治疗方法的不同将82例高龄念球菌性阴道炎患者分成两组,设定为观察组1、观察组2;其中观察组1单独采用酮康唑治疗,观察组2联合酮康唑和克霉唑栓治疗。比较两组治疗前、治疗4周、治疗8周、治疗12周、治疗24周临床症状和体征的评分、治疗效果。结果:治疗前和治疗12周、24周,两组临床症状和体征的评分差异无统计学意义,P>0.05;两组治疗4周、8周的临床症状和体征的评分差异具有统计学意义,P<0.05;两组临床疗效无统计学意义,P>0.05。结论:单独使用酮康唑治疗和酮康唑联合克霉唑栓治疗高龄念球菌性阴道炎的疗效相当,但联合治疗能更快地改善患者的临床症状和体征。
Objective: To observe the effect of ketoconazole alone and ketoconazole combined with clotrimazole suppositories for the treatment of elderly candidal vaginitis. Methods: According to the different treatment methods, 82 cases of elderly patients with Candidal Vaginitis were divided into two groups: observation group 1 and observation group 2, in which observation group 1 was treated with ketoconazole alone and observation group 2 combined with ketoconazole And clotrimazole suppository. The clinical symptoms and signs of the two groups before treatment, 4 weeks of treatment, 8 weeks of treatment, 12 weeks of treatment, and 24 weeks of treatment were compared. Results: There was no significant difference in clinical symptoms and signs between the two groups before treatment, 12 weeks and 24 weeks after treatment, P> 0.05. There was significant difference in scores of clinical symptoms and signs between the two groups at 4 weeks and 8 weeks , P <0.05; the clinical efficacy of the two groups was not statistically significant, P> 0.05. CONCLUSION: Ketoconazole alone and clotrimazole suppository are effective in treating elderly patients with candidal vaginitis, but the combination therapy can improve the clinical symptoms and signs of the patients more quickly.