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乳腺癌是女性最常见的恶性肿瘤之一,且其发病率呈逐年上升的趋势,尽管随着诊疗技术的进步,乳腺癌的死亡率得到了实质性的降低,但它仍是女性肿瘤死亡的第二大原因,目前对乳腺癌的治疗还面临很大的挑战。长链非编码RNA(Longnon-codingRNA,LncRNA)是一类长度超过200个核苷酸的非编码RNA分子,缺乏开放的阅读框,无编码蛋白质的功能。近年来研究发现,LncRNA可能在多种恶性肿瘤的发生、发展、侵袭及转移过程中起调控作用,且目前对其与乳腺癌的关系研究较多,对LncRNA与乳腺癌相关性的研究有望为乳腺癌的诊治提供新思路。现就LncRNA在乳腺癌中的研究进展做一综述。
Breast cancer is one of the most common malignant tumors in women and its incidence has been increasing year by year. Although breast cancer mortality has been substantially reduced with advances in diagnosis and treatment, breast cancer is still the death of female cancer The second reason, the current treatment of breast cancer is still facing great challenges. Long-chain non-coding RNA (LncRNA) is a class of non-coding RNA molecules longer than 200 nucleotides in length, lacking an open reading frame and lacking the function of coding proteins. In recent years, studies have found that LncRNA may play a regulatory role in the occurrence, development, invasion and metastasis of many malignant tumors, and there are many studies on the relationship between LncRNA and breast cancer. The correlation between LncRNA and breast cancer is expected to be Breast cancer diagnosis and treatment to provide new ideas. The progress of LncRNA in breast cancer is reviewed.