多年来,研究者多以高密度脂蛋白(HDL)中的胆固醇作为研究对象,认为HDL-胆固醇与血管系统疾病危险性之间存在负相关关系.但由于胆固醇在HDL中的相对含量少,仅占HDL的15～20%,故其预示价值有一定局限性.近年来对载脂蛋白中的蛋白质成分研究不断深入.其中载脂蛋白D(apoD)是HDL的一种较次要蛋白质,对其结构、功能、代谢等方面的研究亦未广泛开展.尽管如此,已有证据表明,apoD在脂蛋白代谢中发挥着重要作用,并与心血管系统疾病之间存在着一定的关系. 一、概述 Over the years, researchers mostly focused on cholesterol in high-density lipoprotein (HDL) as a negative correlation between the risk of HDL-cholesterol and vascular disease, but due to the relatively low content of cholesterol in HDL, only Accounting for 15 ~ 20% of HDL, so its predictive value has some limitations.In recent years, the study of apoprotein protein components in-depth research.Among them, apolipoprotein D (apoD) is a more important protein in HDL, Its structure, function, metabolism and other aspects of the study has not been widely carried out.However, there is evidence that apoD plays an important role in the metabolism of lipoproteins, and cardiovascular diseases have a certain relationship.First, Overview