论文部分内容阅读
目的：研究低剂量γ射线照射孕鼠，对仔鼠中枢神经系统发育的影响。方法：对孕１３ｄ小鼠进行一次￣（６０）Ｃｏ（１．０Ｇｙ）γ射线全方位照射，用克紫染色法，观察新生零天仔鼠脑形态，ＳＤＳ－ＰＡＧＥ法电泳检测其蛋白结构。结果：照射组鼠脑海马伞腹侧形成异常细胞团，在６５～７０ＫＤ左右出现异常蛋白。结论：低剂量γ射线照时孕鼠，影响仔鼠中枢神经系统的发育，室管膜细胞对照射损伤较敏感。
OBJECTIVE: To study the effect of low dose gamma irradiation on the development of central nervous system in pregnant rats. Methods: Pregnant mice were exposed to γ-rays of ~ (60) Co (1.0Gy) for 15 days. The brain morphology of neonatal offspring rats was observed by Kevlar staining. The protein structure was detected by SDS-PAGE electrophoresis. Results: Abnormal cell mass was formed in the ventral part of the hippocampus of irradiated group, and abnormal protein appeared at about 65 ~ 70KD. CONCLUSION: Pregnant mice irradiated with low dose of γ-rays affect the development of central nervous system of pups and the ependymal cells are more sensitive to irradiation injury.