甲硝唑(MTZ)又称灭滴灵,为硝基类化合物,1957年始用于滴虫病的治疗,以后陆续证明,其对阿米巴病、人体多种寄生虫病,菌痢、伪膜性肠炎、克隆氏病等皆有效。尤近十多年来,由于发现其对厌氧菌感染的卓著疗效而渐引临床普遍关注,并被WHO列为抗感染的基本药物。由于该药具有应用范围广、疗效高、毒性小及用药方便、安全等特点,故其临床应用近年已十分广泛,现将其概述于下。 Metronidazole (MTZ), also known as metronidazole, is a nitro compound, the beginning of 1957 for the treatment of trichomoniasis, later one after another proved that its amoebiasis, a variety of human parasitic diseases, bacillary dysentery, false Membranous enteritis, Crohn’s disease are all effective. In recent ten years, due to its outstanding effect on anaerobic infections, it has attracted widespread clinical attention and is listed as a basic anti-infective drug by WHO. As the drug has a wide range of applications, high efficacy, low toxicity and convenient medication, safety and other characteristics, so its clinical application has been very extensive in recent years, now summarized below.