百日咳菌苗是目前公认有效的菌苗,但是,儿童接种后有少数发生休克、发热、惊厥和虚脱等严重反应,这与百日咳菌苗的毒性有关。为了防止严重反应的发生,需要进行能正确反映百日咳菌苗毒性的实验室检定。本文报导用14种方法对英国和北美的一些DTP的毒性和药理学性能进行实验室检测。所用实验方法除小鼠体重增加试验外,还有组胺致敏、白细胞计数、低血糖、高胰 Pertussis vaccine is currently recognized as effective vaccine, however, a small number of children after vaccination shock, fever, convulsions and collapse and other serious reactions, which pertussis pertussis vaccine toxicity. In order to prevent the occurrence of serious reactions, laboratory tests that correctly reflect the virulence of pertussis should be conducted. This article reports laboratory tests of the toxicity and pharmacological properties of some DTPs in England and North America using 14 methods. Experimental methods used in addition to the test of weight gain in mice, there are histamine sensitization, white blood cell count, hypoglycemia, hyperhidrosis